Results : NuCynta
Tapentadol (trade name Nucynta) is a centrally-acting analgesic with a dual mode of action as an agonist at the μ-opioid receptor and as a norepinephrine reuptake inhibitor.[2] While its action reflects aspects of tramadol and morphine its ability to kill pain is more on the order of hydrocodone and oxycodone, so not as weak as tramadol but not as strong as morphine.[3] Tapentadol is a new molecular entity that is structurally similar to tramadol (Ultram). It has opioid and nonopioid acitivity in a single compound. Tapentadol is FDA approved for the treatment of moderate to severe acute pain. Due to the dual mechanism of action as an opioid agonist and norepinephrine reuptake inhibitor, there is potential for off label use in chronic pain. Doctors use serotonin and norepinephrine reuptake inhibitors in chronic pain management to increase the effectiveness of opioids and, to a lesser extent, NSAIDs (along with other analgesics) against neuropathic pain and from certain specific contributing causes such as fibromyalgia and diabetic neuropathy.
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